New England vs. Indianapolis: This is a hard call. Neither Tom Brady (3 interceptions) nor Peyton Manning (2 interceptions, 0 touchdowns) played their best last weekend, but both did enough to achieve tough wins on the road against the AFC's top ranked teams. The Colts defense is playing extremely well, while Belichick is a master in these situations. Two factors favor the Colts: home field advantage and Adam Vinatieri. The Colts were undefeated at home this season, and Vinatieri is the best clutch kicker in NFL history. Look for him to make the difference in a close game against his former team. Prediction: Colts.

New Orleans vs. Chicago: Defense may win championships, but the Bears defense isn't what it was at the start of the season. Shawn Alexander ran all over the Bears last weekend in a game that the Bears should have won handily. This Sunday, Deuce McAllister should be primed to exploit this porous-ness (so should Reggie Bush, if he's able to hold onto the ball). The New Orleans defense may not be stellar, but it doesn't need to be when the Bears quarterback is Rex Grossman. Prediction: Saints.