Hugh Hewitt nails it:
Handed a large majority, the GOP frittered it away. The chief fritterer was Senator McCain and his Gang of 14 and Kennedy-McCain immigration bill, supplemented by a last minute throw down that prevented the NSA bill from progressing or the key judicial nominations from receiving a vote. His accomplice in that master stroke was Senator Graham. Together they cost their friend Mike DeWine his seat in the Senate, and all their Republican colleagues their chairmanships. Senator McCain should rethink his presidential run. Amid the ruins of the GOP’s majority there is a clear culprit.
A second loser was Bill Frist. To be the Majority Leader of a majority that did not lead is lethal to his presidential ambitions. Like Senator McCain, it would be easier on everyone if he just exited the stage.
Obviously, McCain, Graham and Frist aren’t the only ones to blame, but many of the others, like Dennis Hastert, will be on their way back to the private sector.