After a moment's reflection (during this lull courtesy of Citizen Kaine), the most important word of the night emerges to me as "marginalized," contra the word "defeated." Terrorists are to be defeated, but insurgents marginalized. This cuts several ways, but the central message is that defeating the non-terrorist insurgents is not necessary to America's vital interests. By inference, absorbing them into democracy is.
Most important phrase on the domestic front: "we must never give in to the belief that America is in decline, or that our culture is doomed to unravel." Our culture is not doomed but it is unraveling. Building a professional army of scientists and mathematicians is precisely the wrong kind of educational emphasis required for unmarginalizing anywhere but along the bottom line.